Endocrine Abstracts

Macroprolactinaemia, a common phenomenon variably expressed in different assays, influences interpretation of prolactin results, as recognised since 1978. The degree of macroprolactinaemia manifest over time is less well described. We examined how macroprolactin status (based on polyethylene glycol(PEG) precipitation prolactin % recovery) varied over serial measurements in hyperprolactinaemic individuals.Methods: All serum total prolacti...

Background: Diagnosis and treatment guidelines of men with adult-onset testosterone deficiency (TD) were published by the British Society for Sexual Medicine (2017). Laboratory practice has a major role in supporting these with accurate and precise total testosterone (TT) methods and standardised pre- and post-analytical protocols.Objective: Our study investigated whether laboratory practice supported management guidelines of adult-onset TD.<p class=...

Introduction: Previous studies have shown that PCOS (first described 1935) increases the future risk of hypertension and coronary artery disease.Aims: We investigated in women with PCOS, the link between social disadvantage and markers of cardiometabolic risk and how weight gain over time related to social disadvantage.Methods: In a primary care-based study, 1797 women were identified from patients attending one ...

Introduction: Previous studies have shown that PCOS (first described 1935) increases the future risk of hypertension and coronary artery disease.Aims: We investigated in women with PCOS, the link between social disadvantage and markers of cardiometabolic risk and how weight gain over time related to social disadvantage.Methods: In a primary care-based study, 1797 women were identified from patients attending one ...

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...